Agenda

Friday, October 28, 2011

	7:30 AM - 8:00 AM

		Opening Comments

	8:00 AM - 8:10 AM	Why are we here and what are the questions we would like to answer? Naftali Kaminski, MD

	8:10 AM - 8:30 AM	Future directions in lung research James P. Kiley, PhD

	Session 1	The First Frontier - COPD Chairs: Jessica Bon, MD, and John J. Reilly, Jr., MD

	8:30 AM - 8:35 AM	Session Chair Introduction

	8:35 AM - 8:55 AM	Classification of disease heterogeneity in COPD (phenotyping) Frank C. Sciurba, MD

	8:55 AM - 9:15 AM	Genetic epidemiology of COPD Edwin K. Silverman, MD, PhD

	9:15 AM - 9:35 AM	Epigenomics of COPD Peter J. Barnes, FRS

	9:35 AM - 9:55 AM	The COPD transcriptome Avrum Spira, MD, MSc

	9:55 AM - 10:15 AM	Exome sequencing Rasika Mathias, ScD

	10:15 AM - 10:35 AM	PANEL DISCUSSION

	10:35 AM - 10:55 AM	Refreshment Break

	Session 2	Beyond Wheezing - Asthma Chair: Sally Wenzel, MD

	10:55 AM - 11:05 AM	Introduction - Asthma phenotypes Sally Wenzel, MD

	11:05 AM - 11:25 AM	Asthma biomarkers and personalized medicine Prescott Woodruff, MD, MPH

	11:25 AM - 11:45 AM	Genes, allergens and asthma in Puerto Ricans Juan C. Celedon, MD, DrPH

	11:45 AM - 12:05 PM	Asthma, allergy and ethnicity Kathleen C. Barnes, PhD

	12:05 PM - 12:25 PM	Understanding asthma through genomics Scott T. Weiss, MD, MS

	12:25 PM - 12:35 PM	Epigenomics of asthma Carrie V. Breton, ScD

	12:35 PM - 12:55 PM	PANEL DISCUSSION

	Lunch	Featured Lunch Presentation Chair: Naftali Kaminski, MD

	12:55 PM - 2:10 PM	Personalized medicine and health care reform Steven D. Shapiro, MD

	Session 3	Personalizing Acute Lung Injury Chairs: Rama K. Mallampalli, MD, and Bryan McVerry, MD

	2:10 PM - 2:30 PM	We still need mice - dissecting mechanisms of human acute lung injury George D. Leikauf, PhD

	2:30 PM - 2:50 PM	Genomics of acute lung injury Joe G.N. Garcia, MD

	2:50 PM - 3:10 PM	Can we predict the outcome of sepsis and pneumonia patients? Sachin Yende, MD

	3:10 PM - 3:30 PM	PANEL DISCUSSION

	3:30 PM - 3:50 PM	Refreshment Break

	3:50 PM

	Session 4	Bench to Bedside: Industry-Academia Happy Hour Chairs: Mark T. Gladwin, MD, and Clay B. Marsh, MD

	3:50 PM - 4:05 PM	Personalized medicine - the road to translation Clay B. Marsh, MD

	4:05 PM - 5:05 PM	Industry Panel Discussion Thomas R. Martin, MD Marc S. Malandro, PhD Ray Jupp, PhD Ramona L. Doyle, MD

	Post-Scientific Session Events

	5:05 PM - 6:40 PM	Poster Reception

	Banquet Dinner at Heinz History Center

	7:00 PM - 9:00 PM	The NIH Undiagnosed Diseases Program: A model for personalized medicine William A. Gahl, MD, PhD, National Human Genome Research Institute, NIH, DHHS

Saturday, October 29, 2011

	7:30 AM - 8:00 AM



	8:00 AM - 8:05 AM	Welcome Mark T. Gladwin, MD

	8:05 AM - 8:15 AM	Opening Remarks on Genomic Medicine Weiniu Gan, PhD

	Session 5	Information - The Key to Personalized Medicine Chairs: Harry Hochheiser, PhD, and M. Michael Barmada, PhD

	8:15 AM - 8:35 AM	Bioinformatics in clinical medicine Michael J. Becich, MD, PhD

	8:35 AM - 8:55 AM	An integrative approach to lung disease Charles Auffray, PhD

	8:55 AM - 9:15 AM	Driving discovery through data integration John Quackenbush, PhD

	9:15 AM - 9:35 AM	Multilevel gene regulation: from microRNA genes to disease regulatory networks Panayiotis (Takis) Benos, PhD

	9:35 AM - 9:45 AM	Integrative phenotyping framework: Integration of phenomic and genomic data elucidates phenotypes in interstitial lung disease and COPD Don Kang, PhD

	9:45 AM - 10:05 AM	PANEL DISCUSSION

	10:05 AM - 10:25 AM	Refreshment Break

	Session 6	Discovering the Gene is Only the Beginning - Lessons From Monogenic Diseases Chairs: Yingze Zhang, PhD, and Joseph M. Pilewski, MD

	10:25 AM - 10:30 AM	SESSION CHAIR INTRODUCTION

	10:30 AM - 10:50 AM	Monogenic diseases are still complex - the example of Sickle Cell Disease Mark T. Gladwin, MD

	10:50 AM - 11:10 AM	Alpha 1 antitrypsin deficiency: Role of autophagy in liver disease and COPD David H. Perlmutter, MD

	11:10 AM - 11:30 AM	Disease modifier genes in cystic fibrosis Gary Cutting, MD

	11:30 AM - 11:50 AM	The elastic fiber/TGF-beta gene network in rare and common forms of COPD Zsolt Urban, PhD

	11:50 AM - 12:10 PM	PANEL DISCUSSION

	Lunch	Featured Lunch Presentation Chair: Oliver Eickelberg, MD

	12:10 PM - 1:25 PM	From protein degradation to personalized medicine Jacob I. Sznajder, MD

	Session 7	Charting Uncharted Land - Interstitial Lung Disease Chairs: Kevin F. Gibson, MD, and Kristen L. Veraldi, MD, PhD

	1:25 PM - 1:30 PM	SESSION CHAIR INTRODUCTION

	1:30 PM - 1:50 PM	Phenotypes and biomarkers in idiopathic pulmonary fibrosis Fernando Martinez, MD

	1:50 PM - 2:10 PM	Genotypes and phenotypes of sarcoidosis Joachim Muller-Quernheim, MD

	2:10 PM - 2:30 PM	Genetics of idiopathic pulmonary fibrosis David A. Schwartz, MD, MPH

	2:30 PM - 2:50 PM	Genomics and personalized medicine in idiopathic pulmonary fibrosis Naftali Kaminski, MD

	2:50 PM - 3:00 PM	Epigenomics of idiopathic pulmonary fibrosis Ivana V. Yang, PhD

	3:00 PM - 3:20 PM	PANEL DISCUSSION

	3:20 PM - 3:40 PM	Refreshment Break

	Session 8	Genomics of Pulmonary Hypertension and Sleep Chairs: Hunter Champion, MD, PhD, and Charles W. Atwood, MD

	3:40 PM - 3:45 PM	Session Chair Introduction

	3:45 PM - 4:10 PM	Idiopathic pulmonary arterial hypertension - clinical characteristics and survival Marc Humbert, MD, PhD

	4:10 PM - 4:30 PM	Genetics of pulmonary arterial hypertension James E. Loyd, MD

	4:30 PM - 4:50 PM	Genomics of sleep and its disorders Allan I. Pack, MD, PhD

	4:50 PM - 5:10 PM	PANEL DISCUSSION

	Conference Summary

	5:10 PM - 5:30 PM	John J. Reilly, Jr., MD

	5:30 PM	Adjournment