1:00 PM - 1:05 PM

Overview
Gregory J. Kato, MD

1:05 PM - 1:10 PM

Welcome
Henrietta D. Hyatt-Knorr, MA, Office of Rare Diseases

DISRUPTED NITRIC OXIDE METABOLISM AND OXIDATIVE STRESS
Chairs: Constance Tom Noguchi, PhD and Jeffery L. Miller, MD

Oxidation, Hemostatic Activation and Adhesion
Robert P. Hebbel, MD

Nitric Oxide Scavenging by Cell-Free Plasma Hemoglobin
Mark T. Gladwin, MD

Catalytic Nitric Oxide Scavenging by Oxidases and Oxygenases
Bruce Freeman, PhD

2:40 PM - 3:00 PM

BREAK

VASCULAR DYSFUNCTION AND CELL ADHESION
Chairs: Robert P. Hebbel, MD and Marie J. Stuart, MD

3:00 PM - 3:30 PM

Nitric oxide resistance in the sickle cell mouse
Dhananjay K. Kaul, PhD

3:30 PM - 4:00 PM

Mediators of cell adhesion in sickle cell disease
Paul S. Frenette, MD

Endothelial dysfunction in the sickle cell mouse
Cheryl A. Hillery, MD

Glutathione dysregulation in sickle cell disease
Claudia R. Morris, MD

Poster Session (Attended reception)

HEMOSTATIC ACTIVATION AND GENOMICS OF VASCULOPATHY
Chairs: James G. Taylor, VI, MD and Mary E. Fabry, PhD

8:00 AM - 8:30 AM

Hemostatic activation in sickle cell disease
Kenneth I. Ataga, MD

OTHER VASCULOPATHIES

8:30 AM - 9:00 AM

Hemolytic rate and risk of stroke in children with sickle cell disease
Françoise Bernaudin, MD

Low nitric oxide bioactivity and priapism
Hunter C. Champion, MD, PhD

GENOMICS OF VASCULAR COMPLICATIONS

Genomic markers of sickle cell priapism and leg ulcers
Martin H. Steinberg, MD

10:00 AM - 10:30 AM

Genomic markers of sickle cell pulmonary hypertension
Marilyn J. Telen, MD

10:30 AM - 10:50 AM

BREAK

TRANSLATIONAL THERAPEUTICS
Chairs: John Fitzgerald Tisdale, MD and Lewis L. Hsu, MD, PhD

10:50 AM - 11:20 AM

Vascular targets for small molecule therapeutics
Gregory J. Kato, MD

Cellular approaches for gene therapy for sickle cell disease
Tim M. Townes, PhD

Poster Session and lunch

ATHEROSCLEROSIS: PARALLELS WITH SICKLE VASCULOPATHY?
Chairs: Gregory J. Kato, MD and Gregory M. Vercellotti, MD

The role of hypertriglyceridemia in atherosclerosis
Anh Le, PhD

Apolipoproteins in sickle cell vasculopathy
Kirkwood A. Pritchard, Jr., PhD

Systolic hypertension in vasculopathy: Lessons from the
Framingham heart study
Daniel Levy, MD

NOS uncoupling in vascular disease
David A. Kass, MD

Closing Remarks

BREAK

4:00 PM - 6:00 PM

Topics for Future Research