The National Institutes of Health and The Johns Hopkins University School of

Medicine present the Workshop on Vasculopathy in Sickle Cell Disease

DISRUPTED NITRIC OXIDE METABOLISM AND OXIDATIVE STRESS

Oxidation, hemostatic activation and adhesion

Nitric oxide scavenging by cell-free plasma hemoglobin

Catalytic nitric oxide scavenging by oxidases and oxygenases


VASCULAR DYSFUNCTION AND CELL ADHESION

Nitric oxide resistance in the sickle cell mouse

Mediators of cell adhesion in sickle cell disease

Endothelial dysfunction in the sickle cell mouse

Glutathione dysregulation in sickle cell disease


HEMOSTATIC ACTIVATION AND GENOMICS OF VASCULOPATHY

Hemostatic activation in sickle cell disease

Hemolytic rate and risk of stroke in children with sickle cell disease

Low nitric oxide bioactivity and priapism

Genomic markers of sickle cell priapism and leg ulcers

Genomic markers of sickle cell pulmonary hypertension


TRANSLATIONAL THERAPEUTICS

Vascular targets for small molecule therapeutics

Cellular approaches for gene therapy for sickle cell disease


ATHEROSCLEROSIS: PARALLELS WITH SICKLE VASCULOPATHY?

The role of hypertriglyceridemia in atherosclerosis

Apolipoproteins in sickle cell vasculopathy

Systolic hypertension in vasculopathy: Lessons from the Framingham heart study

NOS uncoupling in vascular disease