Manfred Boehm, MD
National Heart, Lung, and Blood Institute
Bethesda, Maryland
Presentation Title
Future Therapies of PH: Antiproliferative Strategies Targeting Cell Cycle Regulators
Dr. Boehm has been an Investigator in the Cardiovascular Branch of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health since 2003. After receiving his medical degree from the Free University of Berlin in 1993, Dr. Boehm completed a two-year residency in internal medicine at the Franz-Volhard-Clinic in Berlin. From 1991 to 1995 he pursued postdoctoral studies under Professor D. Ganten in the Department of Hypertension at the Max Delbrueck-Center for Molecular Medicine (MDC), also in Berlin, and held a research fellowship there from 1996 to 1997. Dr. Boehm then came to the University of Michigan, Ann Arbor, as a research fellow in the Laboratory of Professor E. Nabel at the Cardiovascular Research Center (1997 to 1999). In 1999 he joined NHLBI as a research fellow in the Vascular Biology Section of the Cardiovascular Branch. In addition to these appointments, between 1993 and 1996, Dr. Boehm was a visiting scholar in the Department of Biochemistry at the Free University of Berlin, the Department of Neuroscience at the Karolinska Institute, and the National Laboratory of Medical Molecular Biology at the Chinese Academy of Medical Sciences, in Beijing.
The co-author of numerous peer-reviewed papers and abstracts as well as several book chapters and monographs, Dr. Boehm is a manuscript reviewer for Nature Medicine, Circulation, Circulation Research, Journal of Clinical Investigation, Trends in Cardiovascular Medicine, MolecularTherapy, Hypertension, Journal of Hypertension, European Journal of Pharmacology, and Anaesthesiologist. His most recent award was the FAES Award for Research Excellence from the National Institutes of Health.
Dr. Boehm’s laboratory at NHLBI is currently investigating stem cell-mediated vascular regeneration and exploring the origin of cells involved in this process by genetic lineage tracking. Subsequent studies aim to identify the molecular pathways of stem cell differentiation and their interaction with the local microenvironment during vascular remodeling. In closely related studies, Dr. Boehm and his colleagues are investigating the properties of adult (MAPC, MSC) and embryonic stem cells in clinically relevant models of hind limb ischemia and myocardial infarction.