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Department of Health and Human Services          National Institutes of Health

Day 2- Friday, September 7, 2007

Session 5: Nitrite, Ischemia-reperfusion and Mitochondrial Respiration
Session Chairs: David J. Lefer, PhD, Elizabeth Murphy, PhD
8:00 - 8:40 AM Adaptive Tissue Blood Flow and Circulating Nitric Oxide Products in Tibetans at High Altitude
Cynthia M. Beall, PhD
8:40 - 9:10 AM Nitrite Therapy for the Treatment of Ischemia-Reperfusion Injury
David J. Lefer, PhD
9:10 - 9:40 AM The Modulation of Mitochondrial Respiration by Nitrite during Ischemia/Reperfusion
Sruti Shiva, PhD
9:40 - 10:10 AM Role of Xanthine Oxidoreductase in Nitrite-derived NO Production
Amrita Ahluwalia, PhD
10:10 - 10:30 AM Break
Session 6: Nitrite and Cardiac Energetics
Session Chairs: Malte Kelm, MD, PhD and David A. Wink, Jr, PhD
10:30 - 10:55 AM The Nitrite Reductase Function of Deoxmyoglobin Acts as an Oxygen Sensor and Regulates Cardiac Energetics and Function
Tienush Rassaf, MD
10:55 - 11:20 AM Physiological Concentrations of Nitrite modulate Contractility in the Vertebrate Heart
Bruno Tota, MD
Session 7: Nitrite Therapeutics
Session Chairs: Jon O. Lundberg, MD, PhD, and Alan N. Schechter, MD
11:20 - 11:50 AM Cancer and Inflammation: The Dark Side of Nitric Oxide
Steven R. Tannenbaum, PhD
11:50 - 12:15 PM Gastro-protective Role of Nitrate and Nitrite
Lena Holm, PhD
12:15 - 1:15 PM Lunch
1:15 - 1:40 PM Chronic Sodium Nitrite Therapy augments Ischemic Tissue Angiogenesis and Blood Flow
Chris G. Kevil, PhD
1:40 - 2:05 PM Anaerobic killing of mucoid Pseudomonas aeruginosa by Acidified Nitrite Derivatives under Cystic Fibrosis Airway Conditions
Daniel J. Hassett, PhD
2:05 - 2:30 PM Effects of Nitrate on Blood Pressure and Oxygen Utilization in Man
Eddie Weitzberg, MD, PhD  
2:30 - 2:55 PM Inhaled Nebulized Nitrite Reverses Experimental Pulmonary Arterial Hypertension
Brian S. Zuckerbraun, MD
2:55 - 3:20 PM Effects of Nitrite on Lung Transplantation
Kenneth R. McCurry, MD
3:20 - 3:40 PM Break
Oral Podium Presentations - Shorts
Session Chairs: Mark T. Gladwin, MD, and Rakesh T. Patel PhD
3:40 - 3:50 PM #59 Nitrite Repletion after Global Ischemia-Reperfusion Injury results in Improved Survival, Cardiac and Neurological Function in a Mouse Model of Cardiac Arrest
Cameron Dezfulian, MD
3:50 - 4:00 PM #29 Dietary Nitrite Supplementation restores NO/Nitroso Homeostasis in Endothelial Dysfunction and Atherosclerosis
Nathan S. Bryan, PhD
4:00 - 4:10 PM #79 Unexpected O-Binding of Nitrite to Ferric Myoglobin
George B. Richter-Addo, PhD
4:10 - 4:20 PM #48 Hypotensive Effect of Nitrite on Experimental Rat Hypertension is Mediated through Multiple Oxidoreductase-Involved Pathways
Kazuo Ohtake, PhD
4:20 - 4:30 PM #54 Arterial Vs. Venous Nitric Oxide Metabolites in Sepsis Syndrome: A Preliminary Analysis
Anthony P. Pietropaoli, MD
4:30 - 4:40 PM #58 Administration of Nitrite prevents Vasoconstriction after Challenge with Murine Tetrameric Hemoglobin
Binglan Yu, PhD
4:40 PM Meeting Closes