Valentin P. Reutov, PhD, Dr. Biol. Sci.
Institute of Higher Nervous Activity and Neurophysiology,
Russian Academy of Sciences,
Moscow, Russia
Presentation Title
The Nitric Oxide Cycle as a Probable Mechanism Connecting Two Pathways of Nitric Oxide Synthesis in Mammals (Summary of Presentation)
Dr Reutov received his degrees in biophysics (like baccalaureate degrees) at Donetzk State University (Ukraine) in 1974. After PhD training at the Institute of Biological Physics of the USSR Academy of Sciences (Puschino, Moscow Region) and Moscow State University (1974-1977), he pursued physiological training at the Institute of Higher Nervous Activity and Neurophysiology (Moscow, 1978-1987) and at the Moscow State University. Dr Reutov has published articles about nitrite reductase function of deoxyhemoglobin in 1983 and the Nitric Oxide Cycle as mechanism, involving of NO-synthase and nitrite/nitrate-reductase components, as a Mechanism Connecting Two Pathways of NO Synthesis in Mammals in 1993-2002. Dr Reutov received his PhD in 1989 (Moscow State University, Dissertation: “Mechanisms of the reduction of NO2- ions in blood and mitochondria”). He obtained postdoctoral training in biochemistry and physiology at Institute of Higher Nervous Activity and Neurophysiology of Russian Academy Sciences and Moscow State University. Dr Reutov received his Doctor Biological Sciences degrees in physiology and biophysics from Moscow State University (2004). Dr Reutov has published over 200 manuscripts in the fields of physiology, morphology, biochemistry, biophysics, free radical biology and magnetic resonance. He has published 5 books in the field of The Cyclic Nitric Oxide Transformation in Mammals and one book in the field of The Biology and Medicine History. Since 1974, Dr Reutov’s research activities have led to the two major scientific discoveries:
1. The Nitrite Reductase Function of Deoxyhemoglobin (articles: 1) Reutov V.P., Azhipa Ia.I., Kaiushin L.P. (1983) Oxygen as an inhibitor of hemoglobin nitrite reductase activity. Izv. Akad. Nauk SSSR Biol. May-Jun; (3) 408-418. PMID: 6875084 [PubMed –indexed for MEDLINE]. 2) Azhipa Ia.I., Reutov V.P., Kaiushin L.P., Nikishkin E.I. (1983) Conformational isomers of hemoglobin complexes with nitric oxide appearing in the blood after the action of sodium nitrite. Izv. Akad. Nauk SSSR Biol. Mar-Apr; (2) 240-250. PMID: 6304169 [PubMed –indexed for MEDLINE]).
2. The Nitric Oxide Cycle, Involving of NO-synthase and Nitrite/Nitrate Reductase Components, as a Mechanism Connecting Two Pathways of NO Synthesis in Mammals (articles: 1) Reutov V.P., Sorokina E.G., Kaiushin L.P. (1994) The nitric oxide cycle in mammals and nitrite reducing activity of heme-containing proteins. Vopr. Med. Khim. Nov-Dec; 40(6): 31-35. PMID: 7618297 [PubMed - indexed for MEDLINE]. 2) Reutov V.P., Kaiushin L.P., Sorokina E.G. (1994) Physiological role of the nitric oxide cycle in man and animals. Fiziol. Cheloveka. May-Jun; 20 (3): 165-174. PMID: 7958600 [PubMed - indexed for MEDLINE]. 3) Reutov V.P., Sorokina E.G., Pinelis V.G., et al. (1994) Do nitrite ions participate in regulating systems of intra- and intercellular signaling? Vopr. Med. Khim. Nov-Dec; 40 (6): 27-31. PMID: 7618296 [PubMed - indexed for MEDLINE]. 4) Reutov V.P., Sorokina E.G. (1998) NO-syntase and nitrite reductase components of nitric oxide cycle. Biochemistry (Mosc.) 63, 874-884. PMID: 9721340 [PubMed - indexed for MEDLINE]. 5) Reutov V.P. (1999) Biochemical predetermination of the NO synthase and nitrite reductase components of the nitric oxide cycle. Biochemistry (Mosc). May; 64(5):528-542. PMID: 10381613 [PubMed - indexed for MEDLINE]. 6) Reutov V.P. (2002) Nitric Oxide Cycle in mammals and the cyclicity principle. Biochemistry (Mosc.) Mar; 67(3):293-311. PMID: 11970729. [PubMed - indexed for MEDLINE]).