Day 1- Thursday, September 6, 2007

**Session 1: The Nitrate-Nitrite-NO Pathway in Physiology and Therapeutics**
Session Chairs: Mark T. Gladwin, MD and Jon O. Lundberg, MD, PhD
8:00 - 8:05 AM	Welcome and Opening Mark T. Gladwin, MD
8:05 - 8:35 AM	Overview of Role of Nitrate in Human Physiology and Therapeutics Jon O. Lundberg, MD, PhD
8:35 - 9:05 AM	Overview of Role of Nitrite in Human Physiology and Therapeutics Mark T. Gladwin, MD
9:05 - 9:35 AM	New Cardiac Imaging Modalities assessing Effects of NO/Nitrite Malte Kelm, MD, PhD

**Session 2: Mechanisms of Nitrite Bioactivation**
Session Chairs: Jay L. Zweier, MD, PhD and Malte Kelm, MD, PhD
9:35 - 10:05 AM	Nitrite as a Source of Nitric Oxide in the Normal and Ischemic Heart Jay L. Zweier, MD, PhD
10:05 - 10:25 AM	Break
10:25 - 10:50 AM	Mitochondrial Nitrite-dependent NO Production and Hypoxic Signaling in Eukaryotes Robert O. Poyton, PhD
10:50 - 11:15 PM	Reduction of Nitrite to NO by Endothelial Nitric Oxide Synthase E. E. van Faassen, PhD
11:15 - 11:40 PM	Plant Nitrite Reduction as the Source of Plant NO Hideo Yamasaki, PhD
11:40 - 12:50 PM	Lunch / Poster Viewing

**Session 3: Nitrite and Vasodilation**
Session Chairs: Richard O. Cannon, III, MD and Eddie Weitzberg, MD, PhD
12:50 - 1:15 PM	Elucidating the relative roles of Nitrite, ATP and SNO-Hb in mediating red-cell dependent hypoxic vasodilation using the b93cys knockout mouse. Rakesh P. Patel, PhD
1:15 - 1:40 PM	Mechanisms of Nitrite Reduction and Vasodilation in Fish Models Frank Bo Jensen, DsC
1:40 - 2:05 PM	Mechanism of NO Formation, Tolerance and Endocrine Bioactivity of Nitrite Andre Dejam, MD, PhD

**Session 4: Nitrite-heme Biochemistry**
Session Chairs: H. Franklin Bunn, MD and Neil Hogg, PhD
2:05 - 2:30 PM	Mechanism of Nitrite Formation in the Erythrocyte Alan N. Schechter, MD
2:30 - 2:50 PM	Break
2:50 - 3:15 PM	NO Reaction with Nitrite Bound to Methemoglobin Daniel B. Kim-Shapiro, PhD
3:15 - 3:40 PM	Reactions of Heme Models Involving Nitrite. Oxygen atom transfer and Catalytic processes derived from Iron-Nitrite interactions. Peter C. Ford, PhD
3:40 - 4:05 PM	Nitrite Reduction by Hemoglobin: the intermediates and their implications for the release of NO bioactivity from RBCs Joseph M. Rifkind, PhD
4:05- 7:05 PM	Poster Viewing and Discussions Wine, Cheese and Light Refreshments