| Thursday,
September 8, 2005 |
Welcome
|
| 8:00
am |
Mark T. Gladwin, MD
National Heart, Lung, and Blood Institute, NIH
Stephen Groft, PharmD
Office of Rare Diseases, Office of the Director, NIH
|
History of Nitrite as a cGMP Dependent Vasodilator
|
| 8:10
am |
Nitrite In the Blood:
History and Mechanisms
Jack R. Lancaster, Jr., PhD
University of Alabama at Birmingham
|
Session 1
Mechanism of Nitrite Formation
Session Chairs: Malte Kelm, MD, PhD,
David Wink, PhD
|
| 8:40 am |
Chemical
Options of Nitrite in Biological Systems. An Overview of Mechanisms
of Nitrite Formation and Chemistry
David Wink, PhD
National Cancer Institute, NIH
|
| 9:05 am |
Relevance
of Nitrite Formation in the Human Circulation
Malte Kelm, MD, PhD
Heinrich-Heine-Universität Düesseldorf,
Germany
|
| 9:30 am |
A Novel
Mechanism of Nitrite Formation and the Regulation of Mitochondrial
Function
Sruti Shiva, PhD
National Heart, Lung, and Blood Institute, NIH
|
| 9:45 am |
Break
|
Session 2
Mechanism for Enzymatic and Non-Enzymatic Nitrite Reduction
to NO and Nitrating/Nitrosating Intermediates (xanthine oxidoreductase
and disproportionation)
Session Chairs: Bruce Freeman, PhD, Jay L.
Zweier, MD
|
| 10:05 am |
REALLY Yellow
Grease – Fatty Acid Nitroalkene Derivatives Transduce Nitric
Oxide and Nitrite Cell Signaling Activities
Bruce Freeman, PhD
University of Alabama at Birmingham
|
| 10:30 am |
Hypoxic
Regulation of Xanthine Oxidoreductase Activity
Margaret M. Tarpey, MD
University of Alabama at Birmingham
|
| 10:55 am |
Peroxidase
- catalyzed Nitrite Oxidation and Cardiovascular Disease
Stan Hazen, MD, PhD
Lerner Research Institute, The Cleveland Clinic Foundation
|
| 11:20 am |
Nitrite-Mediated
Formation of Nitric Oxide and Nitrosyl-Heme Complexes During
Ischemia
Jay L. Zweier, MD, PhD
Davis Heart and Lung Research Institute, Columbus, OH
|
| 11:45 am |
Nitrite is
a Signaling Molecule and Regulator of Gene Expression in Mammals
Martin Feelisch, PhD
Boston University School of Medicine
|
| 12:10 pm |
Mitochondria
have a Nitrite Reductase Involved in Recycling Nitric Monoxide
from Nitrite
Hans Nohl, PhD
Veterinary University, Vienna, Austria
|
12:25 am |
Lunch
|
Session 3
Bacterial Nitrite Reductase Systems: Nitrite Coordination, Proton
Donation, and Electron Flow
Session Chairs: Michael P. Doyle, PhD,
C.S. Raman, PhD
|
| 1:25pm |
Nitrites
and Hemoglobin - a Retrospective
Michael P. Doyle, PhD
Univeristy of Maryland
|
| 1:50 pm |
Nitrogen
Oxides in Bacteria: Relation to Health and Diseases
C.S. Raman, PhD
The University of Texas Health Science Center at Houston |
| 2:15 pm |
Nitrogen
Oxide Complexes of Copper Nitrite Reductase
Grant Mauk, PhD, MD
University of British Columbia
|
| 2:40 pm |
Break |
Session 4
Ischemia-Reperfusion Injury and Infarction
Session Chairs: Anthony Butler, MD, David J.
Lefer, PhD
|
| 3:00 pm |
Early Use
of Nitrite Therapy
Anthony Butler, MD
University of St. Andrews, Scotland
|
3:30pm
|
Protective
Effects of Nitrite Therapy in Ischemia-Reperfusion Injury
David J. Lefer, PhD
Louisiana State University Health Sciences Center
|
| 3:55 pm |
Nitrite-induced
Cardioprotection: Role of Xanthine Oxidoreductase
Amrita Ahluwalia, PhD
The William Harvey Research Institute London, England
|
| 4:20 pm |
Low Dose
Nitrite Ameliorates Myocardial Ischemia/Reperfusion Injury
and Reduces Infarct Size in a Canine Model
Andrew Arai, MD
National Heart, Lung, and Blood Institute, NIH
|
4:35 pm |
Inhaled
NO and the Treatment of Myocardial Ischemia-Reperfusion Injury
Kenneth Bloch, MD
Massachusetts General Hospital
|
Perspective and Summary Statement
|
| 4:50 pm |
Martin Feelisch,
PhD
Boston University School of Medicine |
| 5:00 pm |
Poster Session / Wine and
Cheese |
