National Heart Lung and Blood Institute
National Institutes of Health, DHHS
Bethesda, Maryland
Session Chair and Organizing Committee
Dr. Sack has been a Principal Investigator at the National Institutes of Health (NIH) in Bethesda since 2003. Before joining NIH, he spent a year at University College London in the United Kingdom, and was then a faculty member at the University of Cape Town Medical School in South Africa (2001-2003).
Dr. Sack received his MD from the University of Witwatersrand Medical School in Johannesburg, South Africa in 1988 and his PhD from the University of Cape Town Medical School in 2000. He completed his Internal Medicine Residency at Georgetown University Medical Center in 1994 and undertook cardiology training at Barnes Hospital and Washington University in St. Louis from 1994 to 1997.
His research has focused on various aspects of the molecular regulation of mitochondrial biology in the context of cardiac hypertrophy, failure, and ischemia, and most recently with the development of diabetes. The focus of his laboratory is to understand the molecular regulatory controls governing mitochondrial function with the development of diabetes and to identify targets to modulate mitochondrial function. These targets are then manipulated to evaluate whether the modulation of mitochondrial regulation can modulate and control diabetes and reverse the cardiac and skeletal muscle perturbations associated with diabetes. His laboratory undertakes basic studies and has active clinical protocols to translate laboratory findings to the patient.
