Departments of Anesthesiology and of Pharmacology and Physiology
University of Rochester Medical Center
Rochester, New York
Mitochondria as the Target of the Cardioprotective Actions of Nitric Oxide
(Oct. 6, 10:25 AM )
Presentation Summary
Since 2003 Dr. Brookes has been Assistant Professor of Anesthesiology and of Pharmacology and Physiology at the University of Rochester Medical Center. Before this position, Dr. Brookes was a Research Assistant Professor (2002-2003) and Research Instructor (2001-1002) at the University of Alabama at Birmingham.
He obtained his PhD in Biochemistry in 1997 at the University of Cambridge in the United Kingdom. He then completed two postdoctoral fellowships: the first at the Institute of Neurology at University College London and the second at the University of Alabama at Birmingham.
Dr. Brookes' lab focuses on the role of mitochondria both in the pathology of cardiac ischemic injury, and in the cardioprotection afforded by ischemic preconditioning. In particular, his work has defined a number of novel pathways by which nitric oxide modulates mitochondrial function. More recently, he has developed a series of mitochondrially-targeted nitric oxide donors that exhibit cardioprotective efficacy.
