8:00 AM—8:05 AM
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Welcome
Michael N. Sack, MD, PhD
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8:05 AM—8:15 AM
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Opening Remarks
Elizabeth G. Nabel, MD
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The Regulatory Control of Mitochondrial Homeostasis
Chair: Daniel P. Kelly, MD
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Proteolytic Control of Mitochondrial Biogenesis and Dynamics
Thomas Langer, PhD
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The PGC Family is Master Regulators of Mitochondrial
Biogenesis
Bruce M. Spiegelman, PhD
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Assembling the Components and Circuitry for Mitochondrial Biogenesis
Vamsi K. Mootha, MD
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9:15 AM—9:35 AM
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Mitochondrial Gene Expression and Signaling in Disease and Aging
Gerald S. Shadel, PhD
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9:35 AM—9:50 AM
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Biological Function
of SIRT5 in Metabolism
Takashi Nakagawa
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9:50 AM—10:25 AM
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BREAK
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Reactive Oxygen Species Biology, Calcium and the Role of
Mitochondria in Signal Transduction
Chair: Toren Finkel, MD, PhD,
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Mechanisms
of Cardioprotection by Nitric Oxide acting at the Mitochondrial
Level
Paul S. Brookes, PhD
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New Perspectives on the Role of Mitochondria in Heart Disease
Brian O'Rourke, PhD
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11:05 AM—11:25 AM
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Keeping Mitochondria
in Shape: A Matter of Life and Death
Luca Scorrano, MD, PhD
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11:25 AM—11:45 AM
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Mitochondrial Production of Reactive Oxygen Species
Dmitry B. Zorov, PhD
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Mitochondrial Pathways for
Reactive Oxygen Species Formation
and Myocardial Injury
Fabio Di Lisa, MD
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12:05 PM—1:35 PM
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Lunch/ Poster Session (Attended)
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Proteomics in Advancing the Understanding of Mitochondrial Biology
Chair: Peipei Ping, PhD
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1:35 PM—1:55 PM
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The Dynamics of the Mitochondrial Proteome
Peipei Ping, PhD
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1:55 PM—2:15 PM
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Mitochondria
in Heart Failure
Jennifer van Eyk, PhD
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2:15 PM—2:35 PM
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Systems Biology of the Mitochondria
Robert S. Balaban, PhD
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Proteomics of
Lysine Acetylation in Mitochondrion
Yingming Zhao
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Imaging of Mitochondrial Function
Chair: Robert S. Balaban, PhD
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Dynamic Cardiac
Mitochondria
W. Jonathan Lederer, MD, PhD
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3:10 PM—3:35 PM
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BREAK
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3:35 PM—3:55 PM
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A Functional Link Between Mitochondrial Morphology and Cell Cycle Progression at G1-S
Jennifer A. Lippincott-Schwartz, PhD
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3:55 PM—4:15 PM
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Mitochondrial Energy Metabolism in the Diabetic Heart
and Skeletal Muscle
Kieran Clarke, PhD
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4:15 PM—4:35 PM
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Mitochondria from Cradle to Grave
Roberta A. Gottlieb, MD
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4:35 PM—4:50 PM
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PDGFR-β Signaling is an Essential Component
of the Cardiac Response to Load Induced Stress
Aarif Y. Khakoo, MD
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4:50 PM—5:00 PM
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Scientific Poster Award Presentation
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Banquet Dinner - Hyatt Regency Bethesda, Ballroom level
Waterford Lalique Suite
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8:00 AM—8:15 AM
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Welcome
Robert S. Balaban, PhD
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Mitochondrial Dysfunction and Genetic Diseases
Chair: Paul M. Hwang, MD, PhD
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8:15 AM—8:35 AM
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Metabolic Basis of Hypertrophic Cardiomyopathy
Hugh Watkins, MD, PhD
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Mitochondrial Dynamics
in Development and Disease
David C. Chan, MD, PhD
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Mitochondria-Targeted Antioxidants as Potential Therapies
Michael P. Murphy, PhD
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9:15 AM—9:30 AM
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Reduced Fatty Acid Metabolism and Elevated Mitochondrial H2O2 Emission are Associated with Decreased PPARα in Diabetic Human Myocardium
Ethan Anderson
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9:30 AM—9:55 AM
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BREAK
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Mitochondrial Role in Increasing Cardiovascular Risk including
Obesity and Type II Diabetes
Chair: Michael N. Sack, MD, PhD
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The Role of Insulin Signaling in Mitochondrial Dysfunction
Evan Dale Abel, MD, PhD
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Mitochondrial Dysfunction and Type 2 Diabetes
Gerald I. Shulman, MD, PhD
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Role of Skeletal Muscle in Human Energy Metabolism
Kong Y. Chen, PhD
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Mitochondrial Function in Cardiovascular Disease- Ischemia, Hypertrophy and Heart Failure
Chair: Elizabeth C. Murphy, PhD
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10:55 AM—11:15AM
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Connexin 43 in Mitochondria: Functional Importance
Rainer Schulz, MD, PhD
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Molecular Identity of the Mitochondrial Permeability Transition Pore
Christopher P. Baines, PhD
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Cardioprotection and Altered Mitochondiral
Transport
Charles J. Steenbergen, Jr., MD, PhD
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Lunch/Attended Poster Session
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1:25 PM—1:45 PM
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Mitchondrial Function
and Energy Metabolism in Heart Failure
Rong Tian, MD, PhD
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1:45 PM—2:05 PM
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Dysregulation of
the PGC-1 Cascade in the Failing Heart
Daniel P. Kelly, MD
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The Modulation
of Mitochondrial Respiration by Nitrite During Ischemia/Reperfusion
Sruti Shiva, PhD
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The Mitochondria as a Therapeutic Target in Cardiovascular Disease
Chair: HeinrichTaegtmeyer, MD, PhD
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2:25 PM—2:45 PM
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Inhibition of GSK-3β in Cardioprotection
Steven J. Sollott, MD
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2:45 PM—3:05 PM
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Genes and Small Molecules That Slow Aging-Effects on
Cardiovascular Disease
David A. Sinclair, PhD
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3:05 PM—3:30 PM
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BREAK
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3:30 PM—3:50 PM
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Targeting Malonyl CoA Inhibition of Mitochondrial Fatty and Uptake as
an Approach to Treat Cardiac Ischemia
Gary D. Lopaschuk, PhD
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3:50 PM—4:10 PM
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Pre and Postconditioning
:- from Laboratory Bench to Hospital Bedside
Derek M. Yellon PhD, DSc
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4:10 PM—4:30 PM
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Novel Therapies
for Mitochondrial Pathology in Heart Failure
William C. Stanley, PhD
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Closing Remarks
Michael N. Sack, MD, PhD
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