Richard M. Simon, DSc
Biometric Research Branch
National Cancer Institute
Bethesda, Maryland

Presentation Title
Critical Review of Published Microarray Studies for Cancer Outcome
Do’s and Don’ts in Design, Analysis and Reporting (Summary of Presentation)

Dr. Richard Simon is Chief of the Biometric Research Branch of the National Cancer Institute. He holds a doctoral degree in Applied Mathematics and Computer Science from Washington University in St. Louis, Missouri. He has published over 400 papers and developed many of the statistical methods used today in cancer clinical trials. Dr. Simon is an elected member of the American Statistical Association, a former member of the Oncologic Drug Advisory Committee of the U.S. Food and Drug Administration and the National Research Council Committee on Theoretical and Applied Statistics. He is on the Editorial Boards of JNCI, Clinical Cancer Research, Journal of Clinical Oncology, Nature Clinical Practice Oncology, Cancer Investigations, The Cancer Journal, Cancer Informatics and BMC Bioinformatics.

In 1998, Dr. Simon established the Molecular Statistics & Bioinformatics Section and has established a multi-disciplinary group of statistical, mathematical, computational, physical and biological scientists to develop and apply methods for the application of genomic data to cancer therapeutics. He has developed new methods for the planning and analysis of DNA microarray studies and developed integrated software (BRB-ArrayTools) for the analysis of microarray data  with over 6,000 registered users in 65 countries.  He is the lead author of Design and Analysis of DNA Microarray Investigations. Most recently, his research has included development of clinical trial designs and analysis plans for co-development of cancer drugs and genomic diagnostics in order to identify which patients benefit from new drugs in an efficient manner.