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Functional Genomics of Critical Illness and Injury - Surviving Stress - From Organ Systems to Molecules


Frank R Sharp, MD, FAAN
University of California at Davis
Sacramento, California

Speaker Topic
Blood Genomics of Acute and Chronic Neurological Diseases Including Stroke (Summary of Presentation)


Frank R Sharp MD is Professor of Neurology at the M.I.N.D. Institute at the University of California at Davis. His work has included participating in the development of the 2-deoxyglucose method to map active regions of brain, and the development of the c-fos method to map single activated neurons in the brain. His applied research has included showing that the Hsp70 heat shock protein describes the penumbra around a stroke, that hypoxia-inducible factor mediates preconditioning against stroke, and the discovery of neurogenesis in brain following stroke. His group was the first to demonstrate that different types of acute injury in brain and genetic diseases of brain have specific genomic profiles that are manifested in the brain as well as in the blood.

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