Meeting Overview and Objectives
Overview
This is the second international meeting on Hydrogen Sulfide Biology and its biomedical effects. The First International H2S conference was held in 2009 in Shanghai, where leading investigators in H2S biology initially came together to discuss this important molecule and its effects on cellular redox and chemical biology, signal transduction, and pathophysiological functions during health and disease.
The conference will be unique as it represents a period of rapid growth in understanding of H2S chemistry and biology along with possible translational implications that are important for numerous investigators across a wide range of disciplines. This meeting will significantly advance the field through report and discussion on the latest in H2S basic chemical biology, redox based signaling, and potential implications for physiological and disease processes in this burgeoning area of gasotransmitter research.
The keynote speaker will be Solomon H. Snyder, MD, DSc, DPhil, Professor of Neuroscience from The Johns Hopkins University. We expect 200 scientific researchers to attend this pioneering conference which will host a range of sessions that explore the fascinating capacities of this crucial molecule.
Objective
The educational objectives of this conference relate to the chemistry, redox biology and pathophysiology of hydrogen sulfide and its metabolites in health and disease. Sessions will describe numerous basic research findings of H2S formation, chemistry, and molecular mechanistic effects under physiological and disease conditions. Topics will include the following, among others:
- H2S chemical and redox biology, and its importance for oxygen sensing
- H2S signaling mechanisms at the cellular level
- Importance of endogenous H2S synthase enzymes
- Relationship between H2S and other redox mediators and gasotransmitters
- H2S and associated metabolite measurement techniques
- H2S levels as an indicator of tissue dysfunction and disease
- Molecular, biochemical, and physiological activities of H2S in physiological and pathophysiological states
- Therapeutic potential of H2S-based therapies for cardiovascular disease, ischemic tissue injury, vascular remodeling responses, sepsis, heart failure, gastrointestinal disease, and diabetes
At the end of the conference, participants will demonstrate the following:
- Greater understanding of H2S chemical biology and its associated redox mediated effects
- An understanding of recent discoveries regarding molecular and signaling mechanisms of H2S within cells
- An understanding of H2S cytoprotective effects under these conditions
- Appreciation of the relevancy of these latest discoveries for redox regulation of patho- and physiological processes
- A familiarity with therapeutic implications of H2S for a host of disorders including but not limited to cardiovascular disease, ischemic tissue dysfunction, gastrointestinal disease, sepsis, heart failure, and diabetes
